losartan + hydrochlorothiazide + amlodipine + spironolactone

This is a combination therapy consisting of four antihypertensive medications with complementary mechanisms of action. The combination includes: - Losartan: An angiotensin II receptor blocker (ARB) that works by blocking the vasoactive properties of angiotensin II - Hydrochlorothiazide (HCTZ): A thiazide diuretic that increases sodium and water excretion - Amlodipine: A calcium channel blocker (CCB) that relaxes blood vessels - Spironolactone: An aldosterone receptor antagonist that causes the kidneys to eliminate unneeded water and sodium while reducing potassium loss This quadruple therapy would likely be used for resistant hypertension cases where blood pressure cannot be adequately controlled with fewer agents.