losartan + rosuvastatin + ezetimibe

This is a **combination drug** consisting of three active pharmaceutical ingredients: - **Losartan**: an angiotensin II receptor blocker (ARB) primarily used to treat hypertension and to protect kidneys from damage due to diabetes. - **Rosuvastatin**: an HMG-CoA reductase inhibitor (statin) used to lower cholesterol and prevent cardiovascular disease. - **Ezetimibe**: a cholesterol absorption inhibitor that reduces cholesterol absorption in the small intestine. The rationale for combining these agents is the management of patients with coexisting hypertension and dyslipidemia, targeting both blood pressure and cholesterol. The mechanism of action results from additive effects: losartan acts by blocking the angiotensin II receptor, reducing vasoconstriction; rosuvastatin inhibits hepatic cholesterol synthesis; ezetimibe inhibits intestinal cholesterol absorption. No evidence of a fixed-dose combination product containing all three agents (losartan, rosuvastatin, and ezetimibe) as a single pill or under a unique brand name was found in available sources, though rosuvastatin + ezetimibe combinations exist[1][2][4][5][6][7]. Practically, these drugs may be co-administered (as separate pills) for patients requiring management of both hypertension and dyslipidemia.

Other names

losartan + rosuvastatin + ezetimibe