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lovastatin + berberine
- Development stage
- Preclinical
- Lead developer
- Mogon Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Red Rise (lovastatin + berberine) is a preclinical-stage oral combination product being developed by Mogon Pharmaceuticals, a Swiss pharmaceutical company specializing in drug delivery systems. The formulation combines monacolin K (also referred to as monacoline or mevacolin, and chemically identical to lovastatin), a statin-class HMG-CoA reductase inhibitor derived from red yeast rice, with berberine, a plant-derived alkaloid with antidiabetic and lipid-modulating properties. The product is designed as an improved or modified oral-release tablet intended for cholesterol lowering (hypercholesterolemia), leveraging a synergistic effect between the HMG-CoA reductase inhibition of the statin component and the metabolic regulatory mechanisms of berberine, which include AMPK activation and PCSK9 downregulation.
- Brand names
- Red Rise
- Other names
- monacoline mevacolin + berberinemonacolin K + berberineMonacolineMevacolinBerberine
02
Targets
LDLR (Low-density lipoprotein receptor)KIT (c-KIT proto-oncogene receptor tyrosine kinase)CSF1R (Macrophage colony-stimulating factor receptor)ROCK2 (Rho-associated coiled-coil containing protein kinase 2)PIK3CD (Phosphatidylinositol 3-kinase delta)KCNMA1 (Calcium-activated potassium channel subfamily M alpha member 1)AMPK (Adenosine monophosphate–activated protein kinase)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)
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