LSD + lorazepam

LSD + lorazepam is a non-standard combination of two pharmacologically distinct drugs. LSD (lysergic acid diethylamide) is a potent semi-synthetic hallucinogen that acts primarily as an agonist at serotonin 5-HT2A receptors, producing profound alterations in perception, mood, and cognition[6][8]. Lorazepam is a benzodiazepine anxiolytic that acts as a positive allosteric modulator at the GABA-A receptor complex, enhancing inhibitory neurotransmission and producing sedative, anxiolytic, anticonvulsant, and muscle relaxant effects[4][7]. This combination has no approved medical indication but may be encountered in clinical or recreational settings where lorazepam is used to attenuate or terminate the acute psychological effects of LSD ("trip-killing") or manage adverse reactions such as anxiety or agitation following psychedelic use[5][9]. The safety profile of this combination has not been systematically studied; combining CNS depressants like lorazepam with hallucinogens can increase risks such as impaired judgment, respiratory depression (especially if other depressants are involved), confusion, and potential for addiction[1][7].

Other names

lysergic acid diethylamide + lorazepamacid + Ativan