Drug intelligence / Profile preview

lutein + beta carotene + vitamin e

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination dietary supplement containing three antioxidant nutrients—lutein, beta-carotene, and vitamin E. Lutein is a carotenoid that accumulates in the retina and macula of the eye, where it acts as a light filter and protects ocular tissues from oxidative damage. Beta-carotene is another carotenoid with provitamin A activity; it can be converted by the body into vitamin A as needed. Vitamin E (primarily in the form of alpha-tocopherol) is a fat-soluble antioxidant that helps protect cell membranes from oxidative stress. This combination has been studied for its potential to support eye health, particularly in reducing progression of age-related macular degeneration (AMD). Clinical trials such as AREDS have shown benefits for similar combinations; however, later studies suggest that lutein may be preferable to beta-carotene due to safety concerns with high-dose beta-carotene in smokers[1][4][5]. The mechanism of action involves antioxidation and protection against free radical-induced cellular damage.

02

Targets

BCO1 (Beta-carotene oxygenase 1)

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