Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
LY3039478 + dexamethasone
- Development stage
- Unknown
- Lead developer
- Eli Lilly
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
LY3039478 + dexamethasone is a **combination therapy** composed of LY3039478, an orally available small molecule Notch pathway inhibitor, and dexamethasone, a synthetic glucocorticoid corticosteroid. LY3039478 (also known as Crenigacestat) inhibits the proteolytic cleavage of the Notch receptor, blocking Notch signaling—an oncogenic pathway in several malignancies, including T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Dexamethasone is added both for its cytotoxic anti-leukemic activity and for its protective effect against gastrointestinal toxicity induced by Notch inhibition. The combination has been studied in Phase 1b/2 clinical trials in adult and pediatric patients with relapsed or refractory T-ALL/T-LBL[1][3][5].
- Other names
- Crenigacestat + dexamethasone
02
Targets
GSEC (Gamma-Secretase Complex)
Beyond the preview
Go deeper on LY3039478 + dexamethasone.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on LY3039478 + dexamethasone.