Drug intelligence / Profile preview

lycopene + beta-sitosterol

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Lycopene + beta-sitosterol is a combination dietary supplement marketed primarily for **prostate health** and the management of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Beta-sitosterol is a plant-derived phytosterol that can inhibit 5-α-reductase, reducing the conversion of testosterone to dihydrotestosterone, a hormone involved in prostate enlargement, and may exert pro-apoptotic and anti-inflammatory effects in prostate tissue[1][2]. Lycopene is a carotenoid antioxidant associated with modulation of oxidative stress and potential lipid and blood pressure benefits. The combination is typically positioned as a non-pharmaceutical alternative or adjunct for men with mild urinary symptoms due to BPH, with observed benefits including modest improvement in IPSS (International Prostate Symptom Score), decreased nocturia, and reduced LDL cholesterol.

02

Targets

SRD5A (Steroid 5-alpha-reductase)NPC1L1 (Niemann-pick C1-Like 1 transporter)AR (Adrenergic receptors)

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