Drug intelligence / Profile preview

m-(n,n,n-trimethylammonio)-2,2,2-trifluoro-1,1-dihydroxyethylbenzene

Development stage
Unknown
Modality
Small Molecules
01

Overview

M-(N,N,N-trimethylammonio)-2,2,2-trifluoro-1,1-dihydroxyethylbenzene is a synthetic small molecule belonging to the class of quaternary ammonium compounds and substituted anilines. It is best known as a potent inhibitor of acetylcholinesterase (AChE), acting as a transition-state analog and exhibiting femtomolar inhibitory potency. This compound has been studied primarily in biochemical research settings for its ability to inhibit AChE with extremely high affinity but has not been developed or approved for therapeutic use[4][7]. Its primary mechanism involves binding to the active site of acetylcholinesterase and preventing the breakdown of acetylcholine.

Other names
N,N,N-trimethyl-3-(2,2,2-trifluoro-1,1-dihydroxyethyl)aniliniumtrimethyl-[3-(2,2,2-trifluoro-1,1-dihydroxyethyl)phenyl]azaniumm-trimethylammonio(2,2,2-trifluoro-1,1-dihydroxyethyl)benzene
02

Targets

Acetylcholinesterase

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