Drug intelligence / Profile preview

Madame Pearl's Children's Cough Syrup

Development stage
Unknown
Lead developer
Luxembourg Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Madame Pearl's Children's Cough Syrup (also known as Madame Pearl's Cough Syrup F2 for Children) is an over-the-counter oral combination cough and cold syrup developed under the 'Madame Pearl's' brand, owned by Luxembourg Medicine Company (a subsidiary of Wai Yuen Tong Medicine and Wang On Group). The product is specifically formulated for children aged 6 to 12 years to relieve cough, phlegm, and symptoms associated with upper respiratory tract infections, common cold, and influenza. It is a multi-ingredient pharmaceutical product containing noscapine hydrochloride (a non-opioid antitussive that acts centrally as a sigma-1 receptor agonist), guaifenesin (an expectorant that thins bronchial secretions), chlorpheniramine maleate (a first-generation H1 antihistamine that reduces runny nose and sneezing), and squill liquid extract (a traditional expectorant that promotes mucus clearance). The syrup has a long-established market presence in Hong Kong and is distributed across mainland China, Macau, and other regions.

Brand names
Madame Pearl's Children's Cough SyrupMadame Pearl's Cough Syrup F2 (For Children)Madame Pearl's Cough Syrup F2 for Children珮夫人兒童止咳露珮夫人小兒咳露珮夫人小兒咳露F2
Other names
chlorphenamine + guaifenesin + noscapine + squillchlorpheniramine + guaifenesin + noscapine + squillchlorpheniramine maleate + guaifenesin + noscapine hydrochloride + squill liquid extract
02

Targets

Bradykinin B2 receptorHRH1 (Histamine H1 Receptor)NMDAR (Glutamate receptor ionotropic, NMDA)mAChR (Muscarinic acetylcholine receptors)SERT (Sodium-dependent serotonin transporter)SIGMAR1 (Sigma non-opioid intracellular receptor 1)ATP1A (Sodium/potassium-transporting ATPase)TUBB (Tubulin (alpha and beta subunits))

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