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MAGE-A1 + MAGE-A3 + NY-ESO-1 Vaccine
- Development stage
- Phase 1
- Lead developer
- Cancer Research UK
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal, Subcutaneous, Intravenous
01
Overview
The MAGE-A1 + MAGE-A3 + NY-ESO-1 Vaccine is an investigational cancer vaccine composed of overlapping peptides derived from the full-length tumor-associated antigens (TAAs) MAGE-A1, MAGE-A3, and NY-ESO-1. These antigens are commonly overexpressed in a variety of solid tumors. The vaccine is typically administered using autologous dendritic cells pulsed with these peptides to stimulate an antigen-specific immune response against cancer cells expressing these TAAs. The mechanism involves priming the patient’s immune system—particularly T cells—to recognize and attack tumor cells displaying these antigens. This approach has been studied primarily in pediatric patients with relapsed or refractory solid tumors such as neuroblastoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma[2][6][3]. Clinical trials have demonstrated feasibility and tolerability for this regimen when combined with agents like decitabine to enhance antigen expression on tumor cells[2][7].
- Other names
- MAGE-A1, MAGE-A3, and NY-ESO-1 peptides vaccine
02
Targets
NY-ESO-1 (New york esophageal squamous cell carcinoma 1)MAGEA1 (Melanoma-associated antigen 1)MAGEA3 (Melanoma-associated antigen 3)
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