Drug intelligence / Profile preview

magnesium + aluminum antacids

Development stage
Unknown
Lead developer
Sanofi
Modality
Small Molecules
Administration
Oral
01

Overview

Magnesium + aluminum antacids are combination drugs used to relieve symptoms from excess stomach acid, such as heartburn, indigestion, sour stomach, and bloating. They commonly contain aluminum hydroxide and a magnesium salt (often magnesium hydroxide or magnesium trisilicate). The mechanism of action involves neutralizing gastric acid via a chemical reaction, raising the pH and reducing irritation. Magnesium component may cause diarrhea, while the aluminum component may cause constipation; used together, these effects can balance each other. They do not inhibit acid secretion, but rather neutralize pre-existing stomach acid. Some products include simethicone for relief of gas and bloating. These antacids are primarily available as over-the-counter oral suspensions, tablets, or chewables. They are intended for short-term symptomatic relief, not for long-term management of acid-related disorders.[1][2][5][7][8]

Brand names
GavisconMaaloxMylanta
Other names
aluminum/magnesium antacidsaluminum hydroxide + magnesium hydroxidealuminum hydroxide/magnesium trisilicate
02

Targets

PEP (Pepsin)Bile salts and inorganic phosphates in the gastric/duodenal lumen

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