magnesium sulfate + sodium chloride

Magnesium sulfate in normal saline is an intravenous investigational preparation used in clinical research to evaluate its anesthetic-sparing and analgesic properties. Magnesium sulfate acts as a non-competitive NMDA (N-methyl-D-aspartate) receptor antagonist and calcium channel blocker, which modulates pain signaling and reduces the requirement for opioids and volatile anesthetics during and after surgery. In clinical trials, such as those conducted by Aretaieion University Hospital, it is administered as a bolus followed by a continuous infusion to patients undergoing elective procedures like laparoscopic cholecystectomy to improve recovery outcomes and manage postoperative pain. The preparation consists of the inorganic salt magnesium sulfate dissolved in a 0.9% sodium chloride solution.

Other names

magnesium sulfate in 0.9% sodium chloridemagnesium sulphate + normal salinemagnesium + normal saline