Drug intelligence / Profile preview

Maintenance ICS + SABA

Development stage
Unknown
Lead developer
Washington University School of Medicine
Modality
Small Molecules
Administration
Inhalation
01

Overview

Maintenance ICS + SABA refers to a therapeutic regimen for asthma management, specifically evaluated by the Washington University School of Medicine in adolescent patients with poor adherence to daily maintenance inhalers. This regimen consists of a daily maintenance inhaled corticosteroid (ICS), such as fluticasone propionate (Flovent), to control underlying airway inflammation, and an as-needed short-acting beta-agonist (SABA), such as albuterol, for the rapid relief of acute symptoms. In the context of clinical research (e.g., NCT04197453), this standard-of-care approach is used as a comparator to assess the efficacy of symptom-driven ICS/LABA (long-acting beta-agonist) therapy in improving asthma control and reducing hospitalizations in non-adherent populations.

Brand names
Flovent
Other names
Maintenance ICS and Symptom Driven SABAMaintenance ICS and as-needed SABAMaintenance inhaled corticosteroid and as-needed short-acting beta-agonist
02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)

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