Drug intelligence / Profile preview

maltodextrin + caffeine

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Maltodextrin + caffeine is a combination product typically used as a dietary supplement or as part of sports and cognitive performance products. Caffeine is a central nervous system stimulant of the methylxanthine class, acting primarily as a non-selective adenosine receptor antagonist, with additional effects on phosphodiesterase inhibition and catecholamine release, leading to increased alertness, enhanced exercise performance, and cognitive effects[2][3][5]. Maltodextrin is a polysaccharide carbohydrate, easily digestible and commonly used as a food additive for energy replenishment, with no known direct pharmacological activity but potentially able to affect brain reward pathways via oral sensing and rapid glucose availability[4][1][3][5]. The combination has been studied in the context of mouth rinses and ingestion for reduction of cognitive fatigue and improved exercise performance[1][3][5].

02

Targets

ADORA2A (Adenosine A₂A Receptor)TAS1R3 (Sweet taste receptor T1R3 subunit)PDE (Phosphodiesterase family)ADORA1 (Adenosine receptor A1 subtype)

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