mannitol + sodium lactate

Mannitol + sodium lactate is an intravenous solution used primarily as an osmotic diuretic and alkalinizing agent. Mannitol, a sugar alcohol, acts by increasing the osmotic pressure of the glomerular filtrate, which inhibits the tubular reabsorption of water and enhances the excretion of sodium and chloride. This osmotic effect is also utilized to shift fluid from the intracellular and interstitial spaces into the intravascular compartment, effectively reducing intracranial and intraocular pressure. Sodium lactate serves as a metabolic precursor to bicarbonate; upon oxidation in the body, it provides an alkalinizing effect that helps to correct metabolic acidosis and maintain acid-base balance. This combination is frequently employed in neurosurgical procedures, trauma management, and as a priming solution in cardiopulmonary bypass to maintain renal function and manage fluid shifts.

Brand names

Mannitol and Sodium Lactate Injection

Other names

mannitol and sodium lactatemannitol in sodium lactate