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maraviroc + atorvastatin
- Development stage
- Phase 3
- Lead developer
- HealthBio
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Maraviroc + atorvastatin** is an investigational combination therapy in development for the treatment of post-acute sequelae of COVID-19 (PASC, "long COVID"). Maraviroc is a small molecule antagonist of the CCR5 receptor, reducing immune cell trafficking and vascular inflammation, while atorvastatin is a small molecule inhibitor of HMG-CoA reductase, with primary lipid-lowering effects and secondary anti-inflammatory properties. The combination aims to mitigate endothelial inflammation and improve neurocognitive and physical symptoms seen in long COVID by targeting immune dysregulation and vascular injury. Both drugs are FDA-approved for other indications but are being studied here as a novel fixed-dose or co-administered therapy for long COVID[1][3][4][5][6].
- Brand names
- Selzentry + Lipitor
- Other names
- maraviroc and atorvastatinMVC + AtorvastatinIMPACT-LC
02
Targets
CCR5 (C-C chemokine receptor type 5)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)
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