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MCC-CRM-MCM Vaccines B.V.-diphtheria-tetanus-pertussis-poliomyelitis-Haemophilus influenzae type b infection-hepatitis B-meningococcal meningitis (serogroup C)
- Development stage
- Unknown
- Lead developer
- MCM Vaccine Co
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
This designation refers to a specific immunization regimen evaluated in clinical trials, consisting of the concomitant administration of the hexavalent vaccine VAXELIS (V419) and a meningococcal serogroup C conjugate vaccine (MCC-CRM). VAXELIS, developed by MCM Vaccines B.V. (a joint venture between Merck and Sanofi), is a combination vaccine containing diphtheria and tetanus toxoids, acellular pertussis antigens, inactivated poliovirus, Haemophilus influenzae type b conjugate (PRP-OMPC), and recombinant hepatitis B surface antigen. The MCC-CRM component is a separate vaccine targeting Neisseria meningitidis serogroup C, using the CRM197 carrier protein. This co-administration approach is designed to simplify infant immunization schedules by providing protection against seven major pediatric pathogens in a single visit.
- Brand names
- VAXELIS
- Other names
- DTaP-IPV-Hib-HepB + MenC-CRM
02
Targets
FHA (Filamentous hemagglutinin)FIM2/FIM3 (Fimbriae types 2 and 3)HBsAg (Hepatitis B surface antigen)PRN (Pertactin)Diphtheria toxinNeisseria meningitidis group C capsular polysaccharideTT (Tetanus toxoid)OMPC (Meningococcal outer membrane protein complex)
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