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measles, mumps, and rubella vaccine-Children's Mercy Hospital Kansas City-measles-mumps-rubella
- Development stage
- Unknown
- Lead developer
- Children’s Mercy Kansas City
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
This refers to a commercial measles, mumps, and rubella (MMR) vaccine being evaluated in a Phase 4 clinical trial (NCT07195032) sponsored by Children's Mercy Hospital Kansas City. The study investigates the safety and efficacy of the live attenuated vaccine in pediatric heart transplant recipients aged 12 months to 17 years. While MMR vaccines are standard for healthy children, they are typically contraindicated in immunocompromised patients, such as transplant recipients on immunosuppressive therapy. This trial aims to determine if vaccination can be safely performed and provide protective immunity in this high-risk population. The vaccine is a trivalent biologic containing live attenuated strains of the measles, mumps, and rubella viruses, designed to stimulate active immunity through the production of neutralizing antibodies and cellular immune responses.
- Other names
- MMR vaccinelive attenuated measles, mumps, and rubella vaccine
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