Drug intelligence / Profile preview

Mebendazole + Multivitamin

Development stage
Unknown
Lead developer
Johnson & Johnson
Modality
Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Mebendazole + Multivitamin is described here as a combination therapy involving Mebendazole and a Multivitamin supplement. The provided search results do not specifically mention a combination product of mebendazole with multivitamins, but discuss mebendazole as a standalone drug. Mebendazole is an anthelmintic medication used to treat various worm infections, including pinworm, roundworm, whipworm, and hookworm infections. It works by preventing worms from absorbing sugar (glucose), causing them to lose energy and die. Mebendazole is available as a chewable tablet and is typically administered as either a single dose or twice daily for 3 days, depending on the type of infection being treated. Its mechanism of action involves binding to tubulin, inhibiting its polymerization or assembly into microtubules. This leads to degenerative changes in the worm's tegument and intestinal cells, resulting in loss of cytoplasmic microtubules, impaired glucose uptake, depletion of glycogen stores, decreased ATP production, immobilization, and eventual death of the parasite. Notable drug interactions for mebendazole include a usually non-recommended combination with Metronidazole due to the risk of life-threatening skin rashes. Cimetidine can increase mebendazole serum concentration, while Phenytoin and Fosphenytoin can decrease it. Mebendazole can also decrease the excretion of Methotrexate. Common side effects of mebendazole include loss of appetite, stomach pain, and diarrhea. Rare but serious side effects requiring immediate medical attention include black/tarry stools, chills, convulsions, cough/hoarseness, dark urine, fever, hives/skin rash, large hive-like swellings, light-colored stools, and lower back/side pain. Multivitamins are supplements containing multiple vitamins and minerals, generally used for nutritional support. The combination is considered a therapy approach rather than a single drug product.

Other names
mebendazole + multivitaminAnthelminthics and Multivitamins
02

Targets

TUBB (Tubulin (alpha and beta subunits))

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