mebendazole polymorph A + mebendazole polymorph C

Mebendazole is a broad-spectrum anthelmintic drug used to treat parasitic worm infections such as pinworm, whipworm, and roundworm. It acts by binding to the colchicine-sensitive site of β-tubulin in helminths, inhibiting microtubule polymerization and disrupting glucose uptake, leading to parasite death[1][9]. Mebendazole exists in three main crystalline forms (polymorphs): A, B, and C. Polymorphs differ in solubility, bioavailability, and toxicity profiles. Polymorph A is less effective due to poor bioavailability; polymorph C is preferred clinically for its optimal efficacy and lower toxicity compared to B[1][2]. The combination "mebendazole polymorph A + mebendazole polymorph C" refers specifically to a mixture of these two solid-state forms of the drug. This combination is not a standard marketed product but may be encountered in raw materials or during manufacturing processes[5][8].

Other names

mebendazole form A + mebendazole form CMBZ-A + MBZ-C