Drug intelligence / Profile preview

melatonin + cannabinoid

Development stage
Preclinical
Lead developer
Incannex Healthcare
Modality
Small Molecules
Administration
Oral
01

Overview

Melatonin + cannabinoid is a microencapsulated combination drug candidate being developed by APIRx Pharma Sciences for the treatment of sleep disorders. The formulation utilizes microencapsulation technology to deliver melatonin, a hormone that regulates circadian rhythms, alongside a cannabinoid to engage the endocannabinoid system. By targeting both melatonin receptors (MT1 and MT2) and cannabinoid receptors (CB1 and CB2), the therapy aims to provide a synergistic effect on sleep regulation and maintenance. It is currently in the preclinical stage of development, with the microencapsulation intended to optimize the release profile and bioavailability of the active ingredients.

Other names
microencapsulated melatonin + cannabinoidmelatonin + cannabinoid microencapsulation
02

Targets

MTNR1B (Melatonin Receptor 2)CYP1A2 (Cytochrome P450 1A2)CNR1 (Cannabinoid receptor 1)MTNR1A (MT1)PepT1/PepT2 (Peptide transporters 1/2)

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