melatonin + donepezil

Melatonin + donepezil is a combination of two active pharmaceutical ingredients, melatonin and donepezil, investigated primarily for their potential synergistic effects in neurodegenerative disorders such as Alzheimer's disease. Melatonin is an endogenous hormone with antioxidant and neuroprotective properties, while donepezil is a reversible acetylcholinesterase inhibitor used to enhance cholinergic neurotransmission in the brain. The rationale for combining these agents lies in targeting multiple pathophysiological mechanisms involved in Alzheimer's disease—melatonin provides antioxidant and anti-amyloidogenic effects, whereas donepezil improves cognitive function by inhibiting acetylcholinesterase. Recent research has focused on hybrid molecules or co-administration strategies to leverage both anticholinesterase and antioxidant activities for enhanced neuroprotection[1][2][7].