melatonin + griffonia simplicifolia extract + passiflora incarnata extract + eschscholzia californica extract + valeriana officinalis extract + melissa officinalis extract

This is a **combination dietary supplement** typically marketed to aid in **relaxation and sleep support**. It contains: - **Melatonin:** a hormone involved in regulating circadian rhythms and promoting sleep onset by binding to melatonin receptors in the brain. - **Griffonia simplicifolia extract:** an extract containing 5-hydroxytryptophan (5-HTP), a serotonin precursor, which may increase serotonin and melatonin levels, potentially supporting mood, appetite, and sleep[1][3][4]. - **Passiflora incarnata extract (Passionflower):** believed to exert sedative effects and support relaxation, possibly through modulation of GABAergic neurotransmission. - **Eschscholzia californica extract (California poppy):** traditionally used for mild sedative and anxiolytic effects. - **Valeriana officinalis extract (Valerian):** commonly used as a sedative and sleep aid, interacting with GABAergic pathways. - **Melissa officinalis extract (Lemon balm):** used for its calming effects, possibly involving GABA transaminase inhibition. The overall mechanism involves a combination of serotonergic, melatonergic, and GABAergic modulation to promote relaxation and sleep. These ingredients are generally included in **dietary supplements**, not approved pharmaceuticals, and efficacy and safety data are typically limited and based on traditional use, animal studies, or small human studies[1][3][4].