Drug intelligence / Profile preview

melatonin + magnesium

Development stage
Unknown
Lead developer
Natrol
Modality
Small Molecules
Administration
Oral
01

Overview

Melatonin + magnesium is a combination dietary supplement typically formulated to support sleep and relaxation. Melatonin is a hormone produced by the pineal gland, regulating circadian rhythm and promoting sleep onset by acting as an agonist at Melatonin receptor type 1 and type 2 in the central nervous system. Magnesium is an essential mineral that supports over 300 enzymatic reactions, including those related to muscle relaxation, neural transmission, and modulation of circadian timekeeping. Both components may have sleep-promoting effects: melatonin helps induce and regulate sleep, while magnesium may improve sleep quality and duration, potentially by enhancing endogenous melatonin synthesis and modulating GABAergic neurotransmission[1][3]. This combination is primarily indicated for insomnia and sleep disturbances, and clinical studies have shown it can significantly improve sleep quality compared to placebo[1][3].

Other names
melatonin + magnesium
02

Targets

NMDAR (Glutamate receptor ionotropic, NMDA)MTNR1A (MT1)GABRR (GABA-A receptor subunit rho)MTNR1B (Melatonin Receptor 2)

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