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melatonin + magnesium sulfate
- Development stage
- Unknown
- Lead developer
- University of Child Health Sciences and Children's Hospital, Lahore
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Melatonin + magnesium sulfate is an investigational combination therapy being evaluated for its neuroprotective effects in term neonates with hypoxic-ischemic encephalopathy (HIE). Melatonin, an endogenous hormone, acts as a potent antioxidant and free radical scavenger, while magnesium sulfate serves as an inorganic salt that functions as a non-competitive NMDA receptor antagonist. Together, they aim to mitigate brain injury by reducing oxidative stress and excitotoxicity. This combination is currently being studied in Phase 3 clinical trials sponsored by the University of Child Health Sciences and Children's Hospital, Lahore, comparing the dual therapy against magnesium sulfate monotherapy.
- Other names
- magnesium sulfate + melatoninmelatonin and magnesium sulfate
02
Targets
MTNR1A (MT1)NMDAR (Glutamate receptor ionotropic, NMDA)
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