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Drug intelligence / Profile preview
meningococcal group a, c, w-135, and y conjugate vaccine + diphtheria, tetanus, pertussis, hepatitis b, poliomyelitis, and haemophilus influenzae type b vaccine
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
GSK134612 + Infanrix hexa refers to the co-administration of GlaxoSmithKline's investigational tetravalent meningococcal serogroups A, C, W-135, and Y-tetanus toxoid conjugate vaccine (GSK134612, later branded as Nimenrix) with the licensed hexavalent vaccine Infanrix hexa. GSK134612 is a conjugate vaccine targeting *Neisseria meningitidis* bacteria using capsular polysaccharides from four serogroups conjugated to a tetanus toxoid carrier protein. Infanrix hexa is a combined vaccine providing protection against diphtheria, tetanus, pertussis (acellular), hepatitis B (rDNA), poliomyelitis (inactivated), and *Haemophilus influenzae* type b. Clinical trials evaluated the safety and immunogenicity of giving these two vaccines concurrently to infants and toddlers aged 12-23 months, demonstrating that co-administration does not interfere with the immune response or safety profile of either vaccine compared to separate administration.
- Other names
- GSK134612 + Infanrix hexaMenACWY-TT + DTPa-HBV-IPV/Hib
02
Targets
FHA (Filamentous hemagglutinin)PRP (Haemophilus influenzae type b polyribosylribitol phosphate capsular polysaccharide)HBsAg (Hepatitis B surface antigen)Poliovirus type 1 capsid proteinWPV3 (Poliovirus type 3 capsid protein)NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)PRN (Pertactin)TT (Tetanus toxoid)
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