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meningococcal group A and C conjugate vaccine (Sinopharm)
- Development stage
- Unknown
- Lead developer
- Chengdu Institute of Biological Products
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The group A and C meningococcal conjugate vaccine is a bivalent vaccine designed to prevent invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A and C. Unlike pure polysaccharide vaccines, conjugate vaccines chemically link the bacterial capsular polysaccharides to a carrier protein (such as tetanus toxoid or CRM197). This conjugation converts the T-cell independent polysaccharide antigens into T-cell dependent antigens, which induces a more robust immune response, provides longer-lasting immunity, and is effective in infants and young children under two years of age. Several Chinese biopharmaceutical companies, including Chengdu Institute of Biological Products, Chengdu Olin Biotechnology, and Luoyi (Wuxi) Biopharmaceutical, have developed or are evaluating versions of this vaccine in clinical trials to address the prevalence of these serogroups in the region.
- Other names
- Group A and C meningococcal conjugate vaccineMeningococcal Group A and Group C Polysaccharide Conjugate Vaccine
02
Targets
Neisseria meningitidis group C capsular polysaccharideNmA CPS (Neisseria meningitidis group A capsular polysaccharide)
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