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Drug intelligence / Profile preview
meningococcal groups A and C and haemophilus b conjugate vaccine (Zhifei Green Bamboo)
- Development stage
- Unknown
- Lead developer
- Zhifei Biological
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Meningococcal groups A and C and haemophilus b conjugate vaccine (MenAC-Hib) is a trivalent combination conjugate vaccine developed by Beijing Zhifei Lvzhu Biopharmaceutical. It is designed for the active immunization of infants and young children against invasive diseases caused by *Neisseria meningitidis* serogroups A and C and *Haemophilus influenzae* type b (Hib). The vaccine consists of purified capsular polysaccharides from these three pathogens, each individually conjugated to a tetanus toxoid carrier protein. This conjugation converts the polysaccharides from T-cell independent to T-cell dependent antigens, significantly enhancing immunogenicity and inducing immunological memory in infants as young as two months of age. It was the first AC-Hib triple vaccine approved globally and is a key component of pediatric vaccination programs in China.
- Brand names
- Xifeibei
- Other names
- MenAC-Hib vaccineAC-Hib vaccineMeningococcal Groups A and C and Haemophilus b Conjugate VaccineMeningococcal Groups A and C and Haemophilus influenzae type b Conjugate Vaccine
02
Targets
pMHCII (Carrier protein peptide-Major Histocompatibility Complex class II complex)NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharide
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