Drug intelligence / Profile preview

meningococcal polysaccharide group A, C, Y and W135 conjugate vaccine

Development stage
Unknown
Lead developer
Sanofi
Modality
Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

The meningococcal ACYW135 conjugate vaccine developed by Shenzhen Mellow Hope Pharm Industrial is a quadrivalent vaccine indicated for the active immunization against invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A, C, Y, and W135. The vaccine consists of purified capsular polysaccharides from each of the four serogroups, which are individually conjugated to a carrier protein. This conjugation process is critical as it transforms the polysaccharides from T-cell independent antigens into T-cell dependent antigens, thereby inducing a more robust immune response, particularly in infants and young children, and promoting the development of long-term immunological memory. This vaccine is part of the developer's portfolio of biological products aimed at preventing life-threatening bacterial meningitis and sepsis.

Brand names
ACYW135群流脑结合疫苗
Other names
ACYW135群流脑结合疫苗ACYW135 meningococcal conjugate vaccineACYW-135 meningococcal conjugate vaccineACYW 135 meningococcal conjugate vaccinequadrivalent meningococcal conjugate vaccineMCV4MCV-4MCV 4
02

Targets

Neisseria meningitidis group C capsular polysaccharideGroup Y CPS (Neisseria meningitidis group Y capsular polysaccharide)NmA CPS (Neisseria meningitidis group A capsular polysaccharide)MenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)

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