Drug intelligence / Profile preview

meningococcal serogroups A, C, W-135, Y tetanus toxoid conjugate vaccine

Development stage
Unknown
Lead developer
GSK
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Meningococcal serogroups A, C, W-135, Y tetanus toxoid conjugate vaccine (marketed under the brand name Nimenrix) is a quadrivalent conjugate vaccine originally developed by GSK and later acquired by Pfizer. It is indicated for active immunization against invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W-135, and Y. The vaccine consists of purified capsular polysaccharides from each of the four serogroups, each individually conjugated to a tetanus toxoid carrier protein. This conjugation converts the T-cell-independent polysaccharide antigens into T-cell-dependent antigens, enhancing immunogenicity and inducing immunological memory, particularly in infants and young children. It is administered via intramuscular injection.

Brand names
Nimenrix
Other names
meningococcal groups A, C, W-135 and Y conjugate vaccinemeningococcal group A, C, W-135 and Y conjugate vaccine
02

Targets

NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)TT (Tetanus toxoid)

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