menthol + oxygenated glycerol triesters

Menthol + oxygenated glycerol triesters is a topical combination analgesic formulated by adding **oxygenated glycerol triesters** (also referred to as OGTs or essential oxygen oil) to a **mentholated cream**. This combination is designed to treat acute musculoskeletal pain and has been shown in a randomized, double-blind trial to provide significantly greater pain relief, improved mobility, and improved lifestyle measures compared to mentholated cream alone[1][4][5]. **Mechanism of Action:** - **Menthol**: - Activates **Transient receptor potential cation channel subfamily M member 8 (TRPM8)**, producing cooling and analgesic effects in sensory neurons[5]. - At higher concentrations, can also activate **Transient receptor potential cation channel subfamily A member 1 (TRPA1)** and **Transient receptor potential cation channel subfamily V member 3 (TRPV3)**, with variable contributions to analgesia and sensory perception[5]. - Functions as a **positive allosteric modulator** on **Gamma-aminobutyric acid A receptor (GABA-A receptor)** (producing moderate anesthetic effects), and as a **non-competitive inhibitor** of **5-hydroxytryptamine type 3 receptor (5-HT3 receptor)**[5]. - **Oxygenated glycerol triesters**: - Mechanism not clearly elucidated in publicly available studies. Described functionally as a lipid-based substance able to enhance topical analgesia and provide protective, lubricating effects to tissues. - In the context of this combination, OGTs incrementally improve pain relief and tissue comfort when added to the mentholated cream[1][6].

Other names

menthol + OGTmenthol + essential oxygen oilmentholated cream with oxygenated glycerol triesters