mepivacaine hydrochloride + epinephrine

Mepivacaine hydrochloride + epinephrine is a combination pharmaceutical product used for local anesthesia, particularly in dental procedures. Mepivacaine is an amide-type local anesthetic that works by binding to and blocking voltage-gated sodium channels on the neuronal membrane, which prevents the initiation and conduction of nerve impulses. Epinephrine is a sympathomimetic amine that acts as a vasoconstrictor; it is included in the formulation to decrease local blood flow, thereby delaying the systemic absorption of mepivacaine, prolonging its anesthetic effect, and reducing the risk of systemic toxicity. This specific combination (2% mepivacaine with 1:100,000 epinephrine) is frequently used in clinical research, such as studies conducted by the University of Nove de Julho, to evaluate techniques like photobiomodulation for reducing injection-related pain.

Brand names

Mepiadre

Other names

Mepivacaine 2% with Epinephrine 1:100,000