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mesalamine + bacillus clausii

Development stage: Preclinical
Lead developer: Tanta University
Modality: Live Biotherapeutic Products → Microbiome Therapeutics, Small Molecules
Administration: Oral

Overview

Mesalamine + Bacillus clausii is an investigational combination therapy being evaluated by Tanta University for the management of ulcerative colitis. Mesalamine (5-aminosalicylic acid) is a small molecule anti-inflammatory agent that acts locally on the colonic mucosa to inhibit the production of pro-inflammatory cytokines and leukotrienes. Bacillus clausii is a spore-forming probiotic bacterium that helps restore intestinal microbiota balance and may enhance the anti-inflammatory effects of mesalamine. This combination is specifically being studied in patients with ulcerative colitis in remission to evaluate its role in maintaining remission and modulating the gut microbiota.

Other names: mesalamine + Bacillus clausii5-ASA + Bacillus clausiimesalamine + bacillus clausii-Tanta University-ulcerative colitis

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)

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