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mesalazine + vitamin D
- Development stage
- Preclinical
- Lead developer
- Sun Pharmaceutical Industries
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral, Rectal
01
Overview
A combination therapy consisting of mesalazine (also known as mesalamine), an aminosalicylate drug, and vitamin D (cholecalciferol). This combination has been studied for the treatment of ulcerative colitis. Research indicates that vitamin D supplementation enhances the effectiveness of mesalazine in patients with mild to moderate ulcerative colitis by improving Mayo scores, enhancing intestinal barrier function, and reducing inflammatory factors. The combination shows no significant safety concerns compared to conventional treatment alone.
- Other names
- mesalamine + vitamin Dmesalazine + vitamin D3mesalamine + vitamin D3
02
Targets
VDR (Vitamin D receptor)PGHS-1 (Prostaglandin G/H Synthase 1)
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