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mesenchymal stem cell-derived exosomes (Samara Regional Medical Center Dinasty)
- Development stage
- Unknown
- Lead developer
- Samara Regional Medical Center Dinasty
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Inhalation
01
Overview
This investigational therapeutic consists of exosomes (extracellular vesicles) derived from mesenchymal stem cells (MSCs), specifically being evaluated for the treatment of severe COVID-19 pneumonia. These nanoparticles, ranging from 40 to 150 nm in diameter, carry a cargo of bioactive molecules including proteins, lipids, and nucleic acids that possess anti-inflammatory and regenerative properties. The therapy is designed to modulate the immune system's response, potentially preventing the fatal cytokine storm associated with severe SARS-CoV-2 infection, and to stimulate the repair of damaged lung tissue. Developed by the Samara Regional Medical Center Dinasty, the treatment is administered via aerosol inhalation to provide direct delivery to the respiratory tract.
- Other names
- MSC-derived exosomesMSC-Exosexosomes of multi-potent mesenchymal-stromal cells
02
Targets
IL10 (Interleukin-10)
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