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mesenchymal stem cells (University of Liege)
- Development stage
- Unknown
- Lead developer
- University of Liège
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
This investigational cell therapy consists of ex vivo-expanded mesenchymal stem cells (MSCs) typically derived from the bone marrow of third-party donors. Developed by the University of Liege, the therapy is designed to treat severe complications following allogeneic hematopoietic stem cell transplantation (HCT). The MSCs possess potent immunomodulatory properties, functioning by suppressing the activity of immune effector cells and promoting the induction and expansion of regulatory T cells (Tregs). This mechanism aims to restore immune homeostasis and mitigate the pathological immune responses seen in steroid-refractory acute graft-versus-host disease (GVHD), poor graft function (PGF), and low donor T-cell chimerism. The therapy is currently being evaluated in multicenter Phase II clinical trials.
- Other names
- mesenchymal stem cellsMSCmesenchymal stem cell infusion
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