metadoxine + garlic oil

**Metadoxine + garlic oil** is a combination therapy comprising metadoxine (a salt formed between pyridoxine and pyrrolidone carboxylate) and garlic oil. Metadoxine accelerates the elimination of alcohol and acetaldehyde, inhibits alcohol-induced free radical toxicity, reduces hepatic inflammation (including inducible nitric oxide synthase/iNOS levels), and helps to restore key hepatic enzymes affected in fatty liver disease. Garlic oil exhibits cytochrome P450 2E1 (CYP2E1) inhibition, further reducing oxidative stress and hepatocyte injury due to alcohol. When administered together, these agents act synergistically to reduce hepatic steatosis, restore activities of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), restore fatty acid synthase (FAS) expression, and improve liver function more effectively than when used alone. The primary research and development focus for this combination is the prevention and treatment of alcohol-induced fatty liver and steatohepatitis, with the combination also being considered for restoring and improving liver function after alcohol damage[1][2][3].