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metamizole sodium + paracetamol
- Development stage
- Unknown
- Lead developer
- Istanbul University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Metamizole sodium + paracetamol is a combination of two non-opioid analgesic and antipyretic agents used for the management of acute pain. Metamizole sodium, a pyrazolone derivative, provides potent analgesic, antipyretic, and spasmolytic effects, likely through the inhibition of cyclooxygenase (COX) enzymes and modulation of the endogenous cannabinoid and opioid systems. Paracetamol (acetaminophen) is a para-aminophenol derivative that primarily acts by inhibiting prostaglandin synthesis in the central nervous system. This specific combination was evaluated as a rescue analgesic regimen in a historical cohort study conducted by Istanbul University, focusing on postoperative pain management in patients undergoing bilateral reduction mammoplasty as an adjunct to thoracic paravertebral blocks.
- Other names
- dipyrone + acetaminophenmetamizole + paracetamol
02
Targets
CNR1 (Cannabinoid receptor 1)PGHS-1 (Prostaglandin G/H Synthase 1)Endogenous opioid systemCOX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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