metformin (University of California, Davis)

**Metformin** is an orally administered biguanide antihyperglycemic small molecule that lowers blood glucose primarily by reducing hepatic glucose production and improving peripheral insulin sensitivity. It is approved for type 2 diabetes mellitus. In the University of California, Davis-sponsored NCT02339168 study, a liquid metformin hydrochloride formulation supplied by Aspargo Labs was evaluated with separately administered enzalutamide in a completed Phase 1 study in castration-resistant prostate cancer; the trial assessed safety and the appropriate metformin dose for the combination. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fb90693a-074a-45be-94f4-ed6298b1f4e4))

Other names

1,1-dimethylbiguanidedimethylbiguanidemetformin hydrochloride