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metformin (University of Cincinnati)
- Development stage
- Unknown
- Lead developer
- University of Cincinnati
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Metformin** is an orally administered small-molecule biguanide antihyperglycemic drug approved for type 2 diabetes mellitus. It lowers glucose principally by reducing hepatic glucose production, decreasing intestinal glucose absorption, and improving peripheral insulin sensitivity. In the University of Cincinnati Phase I study NCT02325401, metformin was repurposed as an investigational adjunct to concurrent cisplatin and radiation therapy for locally advanced head and neck squamous cell carcinoma. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45cc673a-e125-4d76-8013-89a089eb0ae9))
- Other names
- dimethylbiguanideN,N-dimethylbiguanide
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ND1 (Mitochondrial electron transport chain complex I)
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