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Drug intelligence / Profile preview
metformin + irinotecan
- Development stage
- Phase 2
- Lead developer
- Hospital de Amor
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Metformin + irinotecan is an investigational drug combination being evaluated for the treatment of refractory metastatic or recurrent colorectal cancer. This specific therapeutic approach was the subject of a Phase II single-arm clinical trial (MetIri) conducted at Barretos Cancer Hospital in Brazil. Metformin, a biguanide small molecule traditionally used for type 2 diabetes, is being repurposed for its ability to activate AMP-activated protein kinase (AMPK), which subsequently inhibits the mechanistic target of rapamycin (mTOR) signaling pathway and alters cancer cell metabolism. Irinotecan is a cytotoxic chemotherapy agent that functions as a DNA topoisomerase 1 inhibitor, preventing DNA religation and causing double-strand breaks. The combination therapy aims to leverage the metabolic stress induced by metformin to enhance the efficacy of irinotecan in patients who have failed standard treatments.
- Other names
- metformin hydrochlorideirinotecan hydrochloride
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)TOP1 (DNA Topoisomerase I)mTOR (Mammalian target of rapamycin kinase)
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