metformin + spironolactone

Metformin combined with spironolactone is a therapeutic combination used primarily for polycystic ovary syndrome (PCOS). This combination leverages complementary mechanisms of action: metformin acts as an insulin sensitizer to improve glucose metabolism and reduce insulin resistance, while spironolactone functions as an antiandrogen medication to reduce elevated androgen levels. Clinical studies have shown that this combination may be more effective than either drug alone in reducing BMI, serum androgen levels, improving menstrual cycle frequency, and enhancing insulin sensitivity in PCOS patients.

Other names

Metformin and SpironolactoneMetformin/Spironolactone combination