Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
metformin + turmeric
- Development stage
- Unknown
- Lead developer
- University of Arkansas
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
metformin + turmeric is a combination therapy being evaluated in a Phase 1 feasibility study at the University of Arkansas for patients with biochemically progressive castration-sensitive prostate cancer (CSPC) receiving intermittent androgen deprivation therapy (iADT). The regimen consists of metformin, a biguanide small molecule traditionally used for type 2 diabetes, and turmeric, a nutraceutical containing the active compound curcumin. Metformin is thought to inhibit tumor growth by activating the AMP-activated protein kinase (AMPK) pathway, inhibiting mTOR, and reducing systemic insulin and IGF-1 levels. Turmeric/curcumin provides complementary activity by inhibiting androgen receptor (AR) signaling, downregulating NF-kB, and modulating various inflammatory and proliferative pathways. The study aims to determine if this nutritional and pharmacological intervention can safely delay PSA relapse in men with CSPC.
- Other names
- Metformin and Turmeric in Castration Sensitive Prostate Cancer on iADT
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)
Beyond the preview
Go deeper on metformin + turmeric.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on metformin + turmeric.