methenamine (Robugen)

Methenamine (marketed under the brand name Antihydral) is a topical antiperspirant used for the treatment of excessive sweating (hyperhidrosis), particularly of the hands, feet, and underarms. Developed by Robugen GmbH & Co. KG, the drug functions as a prodrug that releases formaldehyde upon contact with acidic sweat. The released formaldehyde acts by denaturing proteins at the openings of the sweat gland ducts, effectively creating a physical plug that reduces perspiration. It is an established, approved product available in various topical formulations including ointments, creams, and sprays, and has been used for decades in European markets.

Brand names

AntihydralAntihydral SalbeAntihydral Fusspflege CremeAntihydral Spray

Other names

hexamethylenetetramineanthydral