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methotrexate + etoposide + dexamethasone + pegaspargase (Xinhua Hospital)
- Development stage
- Unknown
- Lead developer
- Xinhua Hospital
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Intravenous, Parenteral
01
Overview
MEDA is a combination chemotherapy regimen consisting of methotrexate, etoposide, dexamethasone, and pegaspargase. It is primarily investigated for the treatment of advanced-stage (Stage IV) extranodal natural killer/T-cell lymphoma (ENKTL), nasal type. The regimen combines an antimetabolite (methotrexate), a topoisomerase II inhibitor (etoposide), a corticosteroid (dexamethasone), and an enzyme that depletes asparagine (pegaspargase). This combination is often followed by autologous hematopoietic stem cell transplantation (Auto-HSCT) to consolidate remission in patients with this aggressive subtype of non-Hodgkin lymphoma.
- Other names
- MEDA regimenMEDA chemotherapy
02
Targets
GR (Glucocorticoid receptor)DHFR (Dihydrofolate reductase)TOP2A (DNA topoisomerase II)
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