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methylcobalamin + nortriptyline + pregabalin
- Development stage
- Unknown
- Lead developer
- Elliott Labs
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Zubinor** is an oral fixed-dose combination of methylcobalamin, nortriptyline, and pregabalin marketed by Elliott Labs for neuropathic pain. Pregabalin binds voltage-gated calcium-channel alpha-2/delta auxiliary subunits to reduce excitatory neurotransmitter release; nortriptyline inhibits norepinephrine and serotonin reuptake, augmenting descending pain-modulatory pathways; and methylcobalamin is an active vitamin B12 form that supports neuronal metabolism and myelin maintenance. The product is marketed as a sustained-release tablet formulation.
- Brand names
- ZubinorZubinor-PG
- Other names
- methylcobalamin + nortriptyline + pregabalin
02
Targets
SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)MTR (Methionine synthase)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)
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