Drug intelligence / Profile preview

methylcobalamin + nortriptyline + pregabalin

Development stage
Unknown
Lead developer
Elliott Labs
Modality
Small Molecules
Administration
Oral
01

Overview

**Zubinor** is an oral fixed-dose combination of methylcobalamin, nortriptyline, and pregabalin marketed by Elliott Labs for neuropathic pain. Pregabalin binds voltage-gated calcium-channel alpha-2/delta auxiliary subunits to reduce excitatory neurotransmitter release; nortriptyline inhibits norepinephrine and serotonin reuptake, augmenting descending pain-modulatory pathways; and methylcobalamin is an active vitamin B12 form that supports neuronal metabolism and myelin maintenance. The product is marketed as a sustained-release tablet formulation.

Brand names
ZubinorZubinor-PG
Other names
methylcobalamin + nortriptyline + pregabalin
02

Targets

MTR (Methionine synthase)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)α2δ (Voltage-gated calcium channel alpha-2-delta subunit)

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