methylcobalamin + nortriptyline + pregabalin (Rivchem Pharmaceuticals)

NEURO RIV NT is a fixed-dose combination sustained-release tablet developed by Rivchem Pharmaceuticals for the management of neuropathic pain, such as diabetic neuropathy, postherpetic neuralgia, and spinal cord injury. The formulation combines three active ingredients with complementary mechanisms: pregabalin, nortriptyline, and methylcobalamin. Pregabalin is an alpha-2-delta ligand that binds to voltage-gated calcium channels in the central nervous system, reducing calcium influx and the subsequent release of excitatory neurotransmitters. Nortriptyline is a tricyclic antidepressant that inhibits the reuptake of norepinephrine and serotonin, thereby enhancing descending inhibitory pain pathways. Methylcobalamin, an active coenzyme form of vitamin B12, acts as a cofactor for methionine synthase, promoting myelin sheath synthesis, axonal regeneration, and nerve repair.

Brand names

Neuro Riv NTNeuro Riv NT Tablet SRNeuro Riv NT Tablets

Other names

methylcobalamin + nortriptyline + pregabalinpregabalin + nortriptyline + methylcobalamin