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methylphenidate (Taihe Pharmaceutical)

Development stage
Preclinical
Lead developer
TAHO Pharmaceuticals
Modality
Small Molecules
Administration
Transdermal
01

Overview

TAH9901 is a transdermal patch formulation of methylphenidate developed by Taihe Pharmaceutical for the treatment of pediatric Attention Deficit Hyperactivity Disorder (ADHD). As a central nervous system stimulant, it acts by inhibiting the reuptake of dopamine and norepinephrine through the blockade of the dopamine transporter (DAT) and norepinephrine transporter (NET), respectively. This inhibition leads to increased concentrations of these catecholamines in the synaptic cleft, enhancing neurotransmission in brain regions associated with attention and impulse control. The transdermal delivery system is designed to provide a controlled, sustained release of the medication, potentially offering improved patient compliance and a smoother pharmacokinetic profile compared to traditional oral formulations.

Other names
Methylphenidate Patch
02

Targets

SERT (Sodium-dependent serotonin transporter)DAT (Dopamine plasma membrane transport protein)NET (Norepinephrine Transporter)

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