methylphenidate + vitamin D

This is a combination therapy consisting of methylphenidate, a central nervous system stimulant primarily used to treat attention-deficit/hyperactivity disorder (ADHD), and vitamin D, a fat-soluble secosteroid involved in calcium homeostasis and bone metabolism. Methylphenidate acts as a norepinephrine–dopamine reuptake inhibitor, increasing the synaptic concentrations of these neurotransmitters in the brain to improve attention and reduce hyperactivity[5]. Vitamin D supplementation has been studied as an adjunctive therapy with methylphenidate for ADHD; evidence suggests it may provide additional improvement in ADHD symptoms, particularly evening symptoms, without significant adverse effects[1][3]. The combination is not available as a fixed-dose pharmaceutical product but refers to concurrent use of both agents.