methylprednisolone + bupivacaine

methylprednisolone + bupivacaine is a combination drug product consisting of a synthetic glucocorticoid and a local anesthetic. In the context of clinical trials conducted by InGeneron, Inc., this specific combination (80 mg methylprednisolone and 0.25% bupivacaine) is utilized as the active control arm for treating symptomatic partial-thickness rotator cuff tears. Methylprednisolone serves as a potent anti-inflammatory agent that mediates its effects through the glucocorticoid receptor, reducing the production of inflammatory cytokines and mediators. Bupivacaine is a long-acting local anesthetic that blocks voltage-gated sodium channels, providing immediate but temporary pain relief. This combination represents the standard of care comparator against which InGeneron's investigational autologous adipose-derived regenerative cell (ADRC) therapy is being evaluated in a pivotal, randomized, double-blind trial.

Brand names

Depo-MedrolMarcaineSensorcaine

Other names

Corticosteroid controlMethylprednisolone and bupivacaine combinationCorticosteroid injection